Announcing the AidPod Mark VIb

We had a bit of a fright when we went to the local Supermarket to buy a crate of Coca-Cola for a presentation we are giving this week to find that the predictable had happened and Zambia Breweries (SABMiller), the Coca-Cola bottler, had capitalised on the new lighter and stumpier bottles we reported on earlier and have produced a more compact crate to match.

Unfortunately the Mark V AidPod does not fit the new crates. The AidPod is too deep and hits the dividers in the crate which means it sits too proud of the bottles. Time for a re-design. So I’ve spent the last couple of days with a new crate working out the new profile of the Mark VI AidPod. Mark VIa, the first attempt at a new design, still had the shoulders as a feature. However, this has always been a bone of contention as it would complicate the production process and make the AidPods more expensive to produce. So the Mark VIb has no shoulders and its cross-section now looks like this (see picture). It is still half-length (116mm approx), just like its predecessor and so 10 ADKs will fit into one crate.

The big question is, is the new design big enough to take all the proposed components of the Anti-Diarrhoea Kit (ADK)?

We have samples of the soap that will be part of the kit and we also have samples of the PedZinc zinc supplements but we have yet to finalise the ORS we will use. So on Saturday (15/10/11) we went into Lusaka to combine a bit of research, into what was available on the market, with the purchase of some ORS samples. When we got home we were able to see if the components would all fit into the new AidPod. Watch the video to find out!

Here is a set of 9 pictures which show the new AidPods in the new crate (you’ll need to be reading this on the blog to see this slideshow I think):

Introducing the Mark V AidPod

Each time I do a significant modification to the AidPod design I feel a strange fondness for the out-going model and then immediately bond with the new one. I said this to Jane and she quipped “That’s how you’ll feel when you get your second wife.” :-)

AidPod Mark V

Anyway, here it is the AidPod Mark V. It’s the same as the Mark IV but about half its length. This means it will be cheaper to produce and will carry the items needed to treat just one episode of diarrhoea (not two). We will be able to get 10 of these into a crate.

Our research tells us that a key determinant of whether a child is given ORS is whether ORS is available in the home at the time the diarrhoea strikes. This led us to think that it would be a good idea to include sufficient items in the AidPod to treat two episodes of diarrhoea. However, more compelling evidence indicates that people living in poverty cannot afford to buy and store. In the slums of Nairobi, they don’t buy tubes of toothpaste, they buy a squirt of toothpaste on their toothbrush when they need it.

We think that having AidPods available in the nearby retail kiosk at an affordable price will be nearly as good as having it in the home. The trial will help us determine whether this is the case.

For a more in-depth discussion on why we are going for a smaller AidPod please see this previous blog post.

 

A mini AidPod anyone?

Mark IV AidPod with PedZinc packages

I had a great meeting yesterday with Chris Griffin at the PI Global offices in London talking about the packaging aspects of the trial. I was also able to loan him the various bottles and a crate, on loan to me from Zambian Breweries. These will obviously be crucial in defining the cross-section of the AidPod. We then went on to talk about the length of the AidPod.

A tension has been emerging with this aspect of the AidPod over the last few months. We had originally envisaged that the AidPod would be the full length of the width of the crate ie about 225mm long. This would be big enough to carry the components to treat at least two episodes of diarrhoea: four sachets of ORS, two courses of Zinc supplements and two 25g bars of soap. This thinking was based on research that showed that the biggest indicator of whether a child gets ORS is whether or not the mother, or care-giver, had ORS available in the home at the time of the attack.

However, this makes the ADK (Anti-Diarrhoea Kit) twice as expensive as it needs to be and goes against the guidelines laid down by the late, great C. K. Prahalad* and others who say that when creating products for consumers earning $1-2 dollars a day, price, a low price, is absolutely crucial. These markets are completely different from more developed markets. In developed markets the starting point when pricing a product is your costs, then you add your margin to arrive at the sale price. In poor markets you need to turn this model on its head. You start from the amount people are able/willing to pay (the price) and then work backwards and design the product with a low enough cost to meet the need and enable a profit margin to be made.

On balance, we have concluded (I think) that we need to take the latter approach and so the ADK will have to be as cheap as possible to produce which points to a mini, or half-length ADK. This has the added benefit that we can get 10, not 5, ADKs in each crate.

But what about the research that indicates that ideally you need ORS and Zinc in the home to maximise the likelihood of treatment? Well, what we are banking on is that having ADKs available in the local retail kiosk is nearly as good as having one in the home. The trial will indicate whether or not we are right.

What is helpful is that, coincidentally, the PedZinc component of the ADK comes in a box which is fully compatible with half-length, mini AidPod – see the image above.

* C.K. Prahalad Fortune at the Bottom of the Pyramid: Eradicating Poverty Through Profits

PedZinc samples arrive from Tanzania

PedZinc in AidPod PedZinc embossed livery

Regular readers will remember a mini-panic that we had back last month when we visited the Medical Stores Limited (MSL) warehouse to find the type of Zinc supplements we wanted but packed in boxes of 100 tablets (10 blister packs of 10 tablets each) – see the picture below.
ZinCfant 20mg

This is a real problem for us for several reasons:

  1. A course of Zinc supplementation is 10-14 tablets for a child 6 months or older and half that for children between 2 and 6 months. This packet contains 10 courses for older children – more than we need and more than the mothers and care-givers we are targeting could afford, or be willing, to buy in a single purchase.
  2. For good reasons, the pharmaceutical regulations apply to the medicine AND the way the medicine is packaged with its labelling, instructions and so on. This means that we would not be able to break these packets down and include just one or two blister packs in the proposed ADKs (Anti-Diarrhoea Kits).
  3. And finally, the boxes are too big to fit in an AidPod!

It was time for a re-think. The Zinc tablets we were expecting to find at MSL were PedZinc produced by Shelys Pharmaceuticals in Tanzania. These are already approved for general sale in Zambia but we still had no idea of the package size. Would these be supplied to boxes of 100 tablets too?

I contacted Shelys Pharmaceuticals and yesterday the PedZinc samples arrived from Tanzania and they are:

  1. Packaged as single blister packs of 10 tablets. The packets have all the required information on the back: tablet description; storage instructions; manufacturer; batch information including date of manufacture and expiry date.
  2. The package also contains a detailed data and instruction sheet.
  3. The packaging is very attractive with embossed printing on the front
  4. Two packets fit very neatly into an AidPod

The attractiveness of the package might seem an odd thing to highlight but the 2009 WHO/UNICEF ReportDiarrhoea : Why children are still dying and what can be done, recommended that products to treat diarrhoea need to be ‘attractive’ to mothers and care-givers and part of this will be the way the product looks. Other research has indicated that ORS is often not seen as ‘medicine’ and this is a drawback. Mothers don’t like to feel that are being ‘palmed off’ with non-medicine – a feeling that applies to mothers the world over I would suspect. PedZinc carries the look and feel of a high quality medicine.

A nice twist to all of this is that Shelys Pharmaceuticals is part of the Sumaria group which also owns the Nyanza Bottling Company Limited and Nyanza Bottling, which is based in Mwanza, is the Coca-Cola bottler for the Lake Region in Tanzania. I’m not the only one to have made this link . . .

Zambia Diary | Day 9 and 10, Visit 3 | Visit round-up

I’m writing this sat at my desk back at home if front of a boarded up window which someone put a brick through while we were away. Luckily, it looks like they were just after the keys for the scooter that belonged to our house minder who was round at the Co-op at the time. Unfortunate enough, but not as bad as it could have been – they didn’t hang about and we’re letting the dog take the credit for that.

We flew back from Zambia yesterday (23/5/11), somewhat delayed, but missing the Volcano Cloud! So, the two days I’m reporting on are Saturday and Sunday – which wind up our third and final planning trip to Zambia, before we get the pilot started.

On Saturday I woke up to an email from Jay at the pharmaceuticals arm of the Sumaria GroupShelys Pharmaceuticals. As I reported last week, we were very concerned after our visit to MSL that the approved Zinc supplements that we want to include in the ADK (Anti-Diarrhoea Kit) were not available in one-course packages. The ones in MSL were in packets of 10 courses – far too many for our needs. So I emailed Shelys to ask about their package sizes and got this reply:

Hello Simon,

Thank you for your mail and interest in PedZinc tabs. As Chris mentioned our current pack is of One blister of 10 tablets. Let me know what are the content of kit. We are planing here with Ministry of Health for a kit with ORS and Zinc tablets. Both products are registered in Zambia.

Regards

Jay

This made my day! Funny how this ColaLife thing can really get to you! PedZinc is on the Pharmaceutical Regulatory Authority‘s approved list in Zambia which makes it a lot easier for us to include it in the ADK. The added benefit is that the packaging looks really attractive and although PedZinc is actually a supplement it looks like ‘real medicine’. One of the reported problems with the uptake of ORS is that it doesn’t look like ‘real medicine’ and when you have walked a long way with a very sick child on your back you want ‘real medicine’.

PedZinc packagesSo why Zinc? In May 2004, WHO/UNICEF issued a joint statement recommending the use of zinc, an essential micronutrient for human growth, development and maintenance of the immune system, and a new formulation oral rehydration solution (ORS), with reduced levels of glucose and salt, as a two-pronged approach to improved case management of acute diarrhoea in children. (Source: rehydrate.org/zinc/pdf/puzon.pdf). Zinc supplements reduce the duration of an episode of diarrhoea and protect against future bouts of diarrhoea for two to three months after the episode.

And so to Sunday (22/5/11) – and a tasteful segue straight from diarrhoea to Sunday Lunch! Sunday was a complete day off and we went to a fantastic lunch at Protea Safari Lodge about 30 minutes drive north of Lusaka with some of our very old friends and some new ones. It was a lovely way to end the week. As we finished eating this character pitched up. A Kudu!

A Kudu joins us after lunch

Even more beautiful close up:

The Kudu - even more beautiful close up

We will now be working flat out to get the final version of the plan in place to put before funders by mid-June.

Onwards and upwards!

Zambia Diary | Day 12 (Part 2), Visit 2 | Friday Field Trip


The last kilometre to Mpepo Rural Health Centre

It takes about an hour and a half to reach Mpepo from Mpika. The Health Centre lies barely a kilometre from the tarmac road. Again we were astonished to see satellite dishes on one or two of the village houses (see above video).

In Zambia, Health Centres, which are government run, serve a number of outlying Health Posts. Fridays are a busy day at the Health Centre. The yard was a jumble of bicycles, umbrellas and people.

Bicycles at Mpepo Rural Health Centre, Mpika, Zambia
Bicycles outside Mpepo Rural Health VCentre

A toddler squeaked in delight every time the wind-driven water pump leaked a spray into the air. A crowd flocked around the entrance: mainly women with babies, but quite a few men with sick children, who these days may find themselves the main care-giver. Since we lived in Zambia in the 80s, life expectancy has dropped from 52 to 37 years, mainly due to HIV/AIDS, leaving many orphans, as well as extended families with only one carer – sometimes just an older child. In the Mpepo clinic catchment, 20% of the population is under 5 and nearly 50% below 15. Among the adult population, there are 2 women to every man.

Demographic data for Mpepo Rural Health Centre
Rural Health Centre demographic data courtesy of Rev Samuel Chitundu

Our contact Dr Nachi Kaunda had tried to call ahead and warn the resident Doctor, Reverend Samuel Chitundu, that we were about to descend on him unexpectedly. We found him sitting in a dark office half taken up with baled mosquito nets ready for distribution, a long queue in front of him. As it turned out, her message had not got through to his mobile, which was on charge. Yet still he received us graciously, and gave us twenty minutes out of his impossibly busy day to listen to what we had to say.

ORS is usually available at Health Centres and Health Posts, and is free. But getting it means a long walk for the care-giver carrying a sick child, a long wait in line, and huge pressure on a single doctor, serving an area of perhaps 30 km radius. Rev Chitundu spoke of the challenges of distribution for medicines. There are peaks in childhood diarrhoea: in the rainy season, and again in April/May when the groundnut harvest brings in a complete change in diet that causes many upset stomachs; an inconvenience for adults but potentially dangerous for children. Yes, he said. The ColaLife idea might work. Sometimes you could find a shop in the gaps between health posts; and in any case – as we were acutely aware of his queue outside – it might help if ORS were available elsewhere. It was definitely worth a trial.

As Malama and Nachi explained that evening, the government is trying to ensure Health Posts are established ‘where the people are’, to provide at least some basic services within reach of communities. Yet still, both they and Rev Chitundu agreed, there are challenges in covering the vast distances.

Shop on the road from mpika to Kasama
Outside a shop on the Kasama road from Mpika

On the way back we decided to do a bit of spontaneous market research to test these insights. We stopped at a couple of roadside shops – one of them sited 10km from the next health service in either direction. We bought a Coke each and one for Yombwe (our guide), and started up a conversation: How many crates of Coke do you get a month? How much does it cost to bring it here? Does the Coke lorry stop off on its way past? Do you sell soap too? How much is that?

There were some surprising insights: now, bottled water sells at the same price as a small glass bottle of Coke in rural areas: 3,000 Kwacha. And where we asked, for every bottle of Coke sold they now sell 2 bottles of water. It’s a bigger bottle. It’s OK to take away.

Then, opening the boot of our car, we produced our own crate of Coke, complete with AidPods. It’s well known in Zambia that Mzungus (white people) tend to do crazy, unfathomable things. But buying a Coke when you already have a WHOLE CRATE of your own in the car? We explained the AidPod. Interest dawned and slowly the questions started to come the other way. Could they keep the AidPod? When would we bring more? Yes, the crate now held 29 units to sell, but the transport cost to bring it in would be the same. Yes, they would sell such a thing. Yes, it was more than an hour’s bike ride to the clinic, and some people had no bike. An oxcart trundled past. At least 3 hours to the clinic in that, and they are a rarity in northern Zambia. There are still a lot more questions to answer, a lot of assumptions to test and a lot of plans to make, but we will get there.

At the DDPS site restaurant that evening, we bumped into a group of mothers and carers from a World Vision child nutrition workshop. Of course, out came the crate with Aidpods: we couldn’t resist running the idea past this impromptu focus group. And once we’d got past the ‘crazy Mzungu’ stage a lively conversation started, as they unpacked the AidPod, looked at the soap and the SODIS bag, and broke open the unfamiliar, orange flavoured ORS packet, to taste it. Shame we never learnt to speak Bemba – must sort that out next time around.

But the AidPod certainly passed the ‘desirability test’. As our meals arrived, the mother to whom we’d passed the AidPod slipped it into her bag. That was the last we saw of it. :-)

Zambia Diary | Day 5, Visit 2 | The Workshop

Zambia Workshop 21 Jan 2011
Group work: indicative skills and participation – for the form used, see below

Jane and I were very pleased with the way the workshop went. It seemed to go very well. I can take no credit for the design, that was down to Jane. I just did the techie bits! Jane put all she’s ever learnt from our workshopper friends into this one! Elizabeth Gray-King will recognise the ‘Wall and Hammer’ technique although we just used red and yellow post-it notes: red for problems and barriers and yellow for solutions and insights.

Everyone we wanted to be there was there – 17 people from 11 organisations. Dr Nilda Lambo from UNICEF kicked the workshop off explaining UNICEF’s interest in the well-being of children in general and ORS/diarrhoea and innovation in particular. Nilda was accompanied by three of her colleagues: Rogers who heads the Mother and Child Health team; Jesper who is a monitoring and evaluation specialist and Precious who is part of the Social Policy and Economic Analysis team and helped with the administration for the workshop.

Other organisations present, in alphabetical order, were: CHAZ (The Churches Health Association of Zambia); JSI; Keepers Zambia Foundation; Medical Stores Limited (MSL); Ministry of Health; SABMiller – Coca-Cola bottler; the Society for Family Health; Transaid and World Vision.

THE PILOT | SOCIAL MARKETING THE PILOT | DISTRIBUTION
A sample of the outputs produced through group working relating to two aspects of the pilot: Social Marketing and Distribution. Red = barrier/problem; Yellow = solution/insight

As well as confronting the challenges we may face moving forward and coming up with solutions to these (with red and yellow Post-Its), we also did group work looking at the level of interest and experience for the different roles in the pilot. The levels we used were:

  1. We have skills and experience in this area;
  2. We have data/intelligence in this area that we would be willing to share;
  3. We would, in principle, be interested in an implementation role in this area;
  4. We would, in principle, be interested in leading in this area

The form we used can be downloaded here: A3 formatA4 format. We’ve ended up with three of these sheets completed by the three groups and these will be invaluable in mapping expertise and interest in the different aspects of the pilot from the different potential partners.

We have a follow-up meeting with UNICEF on Tuesday next week to look at the Logical Framework for the pilot. In the meantime we’ve got a lot to digest whilst we start turning all these workshop outputs into a pilot plan.

Of course, we have no formal commitments yet and there is a way to go before we see signed partnership agreements, but we have made a great start. A big thank-you to all those who gave up their Friday morning to participate and to UNICEF for providing the collaboration platform.

[Those interested in the use of social media, please read on.... We met with Ruth yesterday at Keepers Foundation Zambia for the first time this trip and she had been following this diary since we arrived and so was fully briefed on the meetings we'd had and the people we'd met. At this workshop, at least two participants came with a print out of pages from this blog. So this diary is helping potential pilot partners to keep informed of developments as they happen. Try doing that effectively using email! ]

Zambia Diary | Day 3, Visit 2 | A UNICEF day

Today was a UNICEF day. We spent three hours this morning with the UNICEF team as a follow-up to our initial meeting with them on Monday. This was about drilling down into the detail of a pilot in preparation for the workshop on Friday. This was an incredibly useful exercise and re-confirmed that although ColaLife is a simple idea it’s quite complicated when get to consider exactly how it would be implemented.

A key insight for us from today was the fact that we will be running an ‘Operational Research’ programme NOT a ‘Clinical Research’ programme. This means that we will be measuring the extent to which we can:

  1. Flood the pilot areas with ORS through a private sector supply chain
  2. Create a demand in remote rural communities for AidPod Mother’s Kits
  3. Change behaviour around sanitation, hygiene and the use of ORS/Zinc when diarrhoea strikes

We will not be measuring changes in child survival in this pilot. This would be very complicated and expensive to do and the feeling is that there is enough evidence already that has shown that if you achieve the above outputs the health outcomes follow.

We will spend tomorrow preparing for the workshop on Friday.

Dr Prashant Yadav joins Virtual Advisory Board

Dr Prashant Yadav

Look at virtually any paper or report on drug distribution in developing countries, especially if there’s an element of innovation about it, and the chances are it will have Prashant’s name on it.

Prashant has been guiding us since the end of July as we move towards a pilot of the ColaLife concept. He has helped us refine and focus the concept. We were able to meet Prashant for the first time last month on our field trip to Zambia. He happened to be visiting at the time we were there. Again, he was generous with his time, advice and contacts. We are delighted that Prashant is able to join our Virtual Advisory Board and make public his support for a trial of the ColaLife idea.

About ColaLife, Prashant says:

Consumer product companies such as Coca-Cola have distribution channels with deep reach. At the core of these distribution systems is a system of incentives that ensures high product availability at the point of sale. There are various opportunities of leveraging, learning and collaborating with Coca-Cola and similar distribution models to improve access to health products such as ORS, condoms, zinc, water filtration devices, and many other products with public health needs. ColaLife is a partnership model to achieve this objective.

Here is Prashant’s biography.

:-)

Zambia Diary | Day 12 | Last working day in Zambia

IMG_1496

This is Justina and Royce (with her lovely daughter ‘Memory’) and Jane after a conversation yesterday (22/10/10) afternoon. They spent about an hour talking about caring for children and diarrhoea with Cornelius acting as translator. Justine and Royce live in Ngombe Compound which is a legalised, densely populated settlement on the edge of Lusaka. I filmed the interview (with permission) and I will put this online as soon as I get a decent internet connection. The highlights of the conversation were:

  1. They knew what caused diarrhoea in children and they knew what to do when it happened.
  2. They said diarrhoea was very common and in fact Memory was suffering with it at the time.
  3. They knew about Oral Rehydration Salts which they referred to as ORS or ‘Glucose’.
  4. They said that ORS was often not available.
  5. When it was not available “you just have to use your initiative” talked about mixing up salt and sugar themselves but were worried about the measurements.
  6. Jane introduced the idea of the Mother’s Kit and that fact that this might arrive in Coca-Cola crates. They asked if the kit would be available in the shop or the health clinic.
  7. Initially their strong preference was for it to be available at the clinic. However, it appears that this response was confounded by the need to pay. They would rather travel (walk) further to get ORS for free. Jane talked about a voucher system that would allow mothers to collect kits from shops for free and then they warmed to the idea that the kits might be available in shops. Cost is a crucial issue.
  8. Both women had family in rural areas and they said that ORS was less available in these areas.
  9. Jane showed the women some baby products and they were very interested in these and not unfamiliar with them. If such products were included in a Mother’s Kit their first preference would be for Baby Lotion and then tablets of soap. There was no interest in liquid soap.

After the conversation, Jane gave Justina and Royce bags containing ORS, bars of soap, baby lotion and liquid soap. Royce said she had an immediate need of the ORS and would be giving some to Memory when she got home.

IMG_1490 IMG_1494
Jane and Cornelius preparing for the meeting | Justina, Royce, Jane, Memory and Cornelius

IMG_1486Earlier in the day we’d met with John Makumba of the World Bank and Mark Bennett of i-Connect who were conveniently located in the same building. The meeting with John was very encouraging, the World Bank has an interest in the project delivering Malarial Drugs (ACTs) and Rapid Diagnosis Tests (RDTs) through private sector channels and we can learn from this. Dr Prashant Yadav had a key role in the design of this programme and he is the latest member of our Virtual Advisory Board.

Mark Bennet turns out to be THE person to talk to for all things internet and SMS. A huge fount of knowledge and a sharer. The biggest insight from this meeting was that mobile phone banking is just around the corner ie not as far away as we expected. All Zain agents with permanent premises (ie everyone except the talktime sellers at traffic lights and those under trees on street corners) will effectively become Banks. There are 13,000 of these. Individuals will be able to have up to 3 million Kwacha on their SIM Card. Direct phone to phone transfers will be possible. The system will be Bank of Zambia approved and will link back into the traditional banking system via CitiBank. This will serve the 80% of the population with no bank account. It will revolutionise commerce especially in rural areas where access to cash is an issue.

In Zambia, 85% of the population has a SIM Card. To open a mobile bank account they will just have to complete a form quoting their NRC number. This may become the way to pay teachers and others living in remote rural areas. However, there will be a charge on transactions of 1-2%.

i-Connect also run i-SMS which provides bulk SMS services and they already have experience using this system for health-related messaging.